BDBM50232534 5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine::CHEMBL251906

SMILES: Nc1nc(N)c2c(COc3ccccc3F)cccc2n1

InChI Key: InChIKey=HTKCHSHRTXOEIP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232534   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50232534 (5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...) Show SMILES Nc1nc(N)c2c(COc3ccccc3F)cccc2n1 Show InChI InChI=1S/C15H13FN4O/c16-10-5-1-2-7-12(10)21-8-9-4-3-6-11-13(9)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant DHFR				J Med Chem 51: 449-69 (2008) Article DOI: 10.1021/jm061475p BindingDB Entry DOI: 10.7270/Q27S7NJD
					More data for this Ligand-Target Pair
Scavenger mRNA-decapping enzyme (DcpS) (Homo sapiens (Human))	BDBM50232534 (5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...) Show SMILES Nc1nc(N)c2c(COc3ccccc3F)cccc2n1 Show InChI InChI=1S/C15H13FN4O/c16-10-5-1-2-7-12(10)21-8-9-4-3-6-11-13(9)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DcpS assessed as increase in SMN2 promoter activity				J Med Chem 60: 3094-3108 (2017) Article DOI: 10.1021/acs.jmedchem.7b00124 BindingDB Entry DOI: 10.7270/Q2251MG2
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50232534 (5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...) Show SMILES Nc1nc(N)c2c(COc3ccccc3F)cccc2n1 Show InChI InChI=1S/C15H13FN4O/c16-10-5-1-2-7-12(10)21-8-9-4-3-6-11-13(9)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Concentration required for the inhibition of acetylcholinesterase				J Med Chem 60: 3094-3108 (2017) Article DOI: 10.1021/acs.jmedchem.7b00124 BindingDB Entry DOI: 10.7270/Q2251MG2
					More data for this Ligand-Target Pair