BDBM50246439 CHEMBL4082686

SMILES: Oc1c(C(=O)Nc2ccccc2)c(=O)n(-c2ccccc2)c(=S)n1-c1ccccc1

InChI Key: InChIKey=UUXYDFLCAFPDHQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50246439 (CHEMBL4082686) Show SMILES Oc1c(C(=O)Nc2ccccc2)c(=O)n(-c2ccccc2)c(=S)n1-c1ccccc1 Show InChI InChI=1S/C23H17N3O3S/c27-20(24-16-10-4-1-5-11-16)19-21(28)25(17-12-6-2-7-13-17)23(30)26(22(19)29)18-14-8-3-9-15-18/h1-15,28H,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...				J Med Chem 61: 1375-1379 (2018) Article DOI: 10.1021/acs.jmedchem.7b01388 BindingDB Entry DOI: 10.7270/Q2B56N5T
					More data for this Ligand-Target Pair