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SMILES: CSc1sc(C(=O)Nc2ccon2)c2CCc3cnsc3-c12

InChI Key: InChIKey=GTCHOWGVVHHKBH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248676 (CHEMBL4065027) Show SMILES CSc1sc(C(=O)Nc2ccon2)c2CCc3cnsc3-c12 Show InChI InChI=1S/C14H11N3O2S3/c1-20-14-10-8(3-2-7-6-15-22-11(7)10)12(21-14)13(18)16-9-4-5-19-17-9/h4-6H,2-3H2,1H3,(H,16,17,18)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50248676 (CHEMBL4065027) Show SMILES CSc1sc(C(=O)Nc2ccon2)c2CCc3cnsc3-c12 Show InChI InChI=1S/C14H11N3O2S3/c1-20-14-10-8(3-2-7-6-15-22-11(7)10)12(21-14)13(18)16-9-4-5-19-17-9/h4-6H,2-3H2,1H3,(H,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248676 (CHEMBL4065027) Show SMILES CSc1sc(C(=O)Nc2ccon2)c2CCc3cnsc3-c12 Show InChI InChI=1S/C14H11N3O2S3/c1-20-14-10-8(3-2-7-6-15-22-11(7)10)12(21-14)13(18)16-9-4-5-19-17-9/h4-6H,2-3H2,1H3,(H,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair