BDBM50250180 CHEMBL4101411
SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-n2nc(-c3ccc(OCCN4CCOCC4)cc3)c3c(N)ncnc23)no1
InChI Key: InChIKey=SKDBXDGKLQALIZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM14 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of cKIT (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 426 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRalpha (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of RET (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged CSF1R (538 to 910 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of GST-tagged human DDR1 (440 to 876 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to FLT4 (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 425 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged LCK expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human GST-tagged MKNK2 expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 606 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Binding affinity to PDGFRbeta (unknown origin) by KinomeSCan assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PITSLRE serine/threonine-protein kinase CDC2L1 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of human GST-tagged CDK11 by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Discoidin domain-containing receptor 2 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of GST-tagged human DDR2 (427 to 855 residues) expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK7/Cyclin H/MNAT1 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged CDK7/Cyclin H/MNAT1 expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MV4-11 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM14 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK8/Cyclin C (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in Baculovirus expression system by Z'Lyte assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM4 cells assessed as inhibition of ERK phosphorylation at Thr202/Tyr204 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of FLT3 in human MOLM13 cells assessed as inhibition of Akt phosphorylation at Thr308/Ser473 site after 4 hrs by immunoblotting analysis | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of human HL60 cells-derived His-tagged FLT3 (564 to 993 residues) expressed in baculovirus infected sf9 cells using poly (4:1 Glu, Tyr) as... | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50250180 (CHEMBL4101411) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China. Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) using poly (4:1 Glu, Tyr) as substrate after 1 hr by ADP-Glo kinase assay | J Med Chem 60: 8407-8424 (2017) Article DOI: 10.1021/acs.jmedchem.7b00840 BindingDB Entry DOI: 10.7270/Q2474D9S | |||||||||||
More data for this Ligand-Target Pair |