BDBM50255902 CHEMBL4066141

SMILES: CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl

InChI Key: InChIKey=AEGUMSWRCVNPKS-VWLOTQADSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50255902   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged FLT3 (564 to 958 residues) expressed in baculovirus using poly (Glu,Tyr) as substrate after 2 hrs by PK-Li...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant cytoplasmic human His-tagged KIT expressed in baculovirus using Ser/Thr 6 peptide as substrate after 1 hr by FRET-based Z'-...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of cytoplasmic recombinant human His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of cytoplasmic recombinant human His-tagged FGFR4 (781 to 1338 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 ...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of cytoplasmic recombinant human His-tagged FGFR3 (399 to 806 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of cytoplasmic recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDGFRbeta expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-Glo assay				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50255902 (CHEMBL4066141) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r| Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant cytoplasmic human GST-tagged PDGFRalpha expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr ...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair