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BDBM50262587 3-[4-({3-[(2R,5R)-2,5-Dimethyl-1-pyrrolidinyl]propyl}oxy)phenyl]-4(3H)-quinazolinone::CHEMBL443958

SMILES: C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(cc1)-n1c(C)nc2ccccc2c1=O

InChI Key: InChIKey=SJGNWKLQQZVTKR-QZTJIDSGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50262587   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50262587
PNG
(3-[4-({3-[(2R,5R)-2,5-Dimethyl-1-pyrrolidinyl]prop...)
Show SMILES C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(cc1)-n1c(C)nc2ccccc2c1=O |r|
Show InChI InChI=1S/C24H29N3O2/c1-17-9-10-18(2)26(17)15-6-16-29-21-13-11-20(12-14-21)27-19(3)25-23-8-5-4-7-22(23)24(27)28/h4-5,7-8,11-14,17-18H,6,9-10,15-16H2,1-3H3/t17-,18-/m1/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cells


J Med Chem 51: 4780-9 (2008)


Article DOI: 10.1021/jm8003834
BindingDB Entry DOI: 10.7270/Q2FQ9WFW
More data for this
Ligand-Target Pair