BDBM50263515 2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-benzo[d]imidazol-1-yl)pyrimidin-4-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol::CHEMBL447107
SMILES: Cc1nc(Nc2cc(ncn2)-n2c(Nc3c(C)cccc3Cl)nc3ccccc23)cc(n1)N1CCN(CCO)CC1
InChI Key: InChIKey=ZFGRQAXIHZXQBZ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as... | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused InsR-mediated proliferation of TEL-InsR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 356 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused KDR-mediated proliferation of TEL-KDR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lyn (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused Lyn-mediated proliferation of TEL-Lyn transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused Src-mediated proliferation of TEL-Src transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50263515 (2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL | Assay Description Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay | Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ | |||||||||||
More data for this Ligand-Target Pair |