BDBM50265561 CHEMBL4073833
SMILES: Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1
InChI Key: InChIKey=BDGKKHWJYBQRIE-HHHXNRCGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of eIF4G-induced full-length human recombinant His6-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us... | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-II (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of eIF4G-induced human recombinant His6-tagged eIF4A2 RNA dependent ATPase activity using single stranded poly(U) RNA as substrate after 4... | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of human recombinant full-length FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells us... | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of human recombinant full-length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using si... | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-III (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us... | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-III (Homo sapiens (Human)) | BDBM50265561 (CHEMBL4073833) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Binding affinity to full-length human recombinant His6-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assay | J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT | |||||||||||
More data for this Ligand-Target Pair |