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BDBM50272235 3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9Hcarbazol-3-yl)propanamide::CHEMBL499601

SMILES: CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12

InChI Key: InChIKey=XFIKTRAACXFYRM-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50272235   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a 1.30n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a 3.80n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assay


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a>2.60n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in Sf9 cells by GTP-europium binding assay


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level


J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair