BDBM50273322 CHEMBL4130251

SMILES: Nc1cccnc1N1CCC(CC1)C(=O)Nc1ccc(c(Cl)c1)-n1nccn1

InChI Key: InChIKey=DECWMEUVVFELTP-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273322   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273322 (CHEMBL4130251) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1ccc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C19H20ClN7O/c20-15-12-14(3-4-17(15)27-23-8-9-24-27)25-19(28)13-5-10-26(11-6-13)18-16(21)2-1-7-22-18/h1-4,7-9,12-13H,5-6,10-11,21H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISA				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273322 (CHEMBL4130251) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1ccc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C19H20ClN7O/c20-15-12-14(3-4-17(15)27-23-8-9-24-27)25-19(28)13-5-10-26(11-6-13)18-16(21)2-1-7-22-18/h1-4,7-9,12-13H,5-6,10-11,21H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of cIAP2 fused MALT1 (unknown origin) expressed in HEK293 cells assessed as suppression of NF-kB activation after 24 hrs by luciferase rep...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273322 (CHEMBL4130251) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1ccc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C19H20ClN7O/c20-15-12-14(3-4-17(15)27-23-8-9-24-27)25-19(28)13-5-10-26(11-6-13)18-16(21)2-1-7-22-18/h1-4,7-9,12-13H,5-6,10-11,21H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair