BDBM50273329 CHEMBL4127375

SMILES: COc1ncc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1Cl

InChI Key: InChIKey=QWGVKJBBIJDMNS-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273329   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273329 (CHEMBL4127375) Show SMILES COc1ncc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C17H18Cl2N4O2/c1-25-17-14(19)9-12(10-21-17)22-16(24)11-4-7-23(8-5-11)15-13(18)3-2-6-20-15/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273329 (CHEMBL4127375) Show SMILES COc1ncc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C17H18Cl2N4O2/c1-25-17-14(19)9-12(10-21-17)22-16(24)11-4-7-23(8-5-11)15-13(18)3-2-6-20-15/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISA				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273329 (CHEMBL4127375) Show SMILES COc1ncc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C17H18Cl2N4O2/c1-25-17-14(19)9-12(10-21-17)22-16(24)11-4-7-23(8-5-11)15-13(18)3-2-6-20-15/h2-3,6,9-11H,4-5,7-8H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of cIAP2 fused MALT1 (unknown origin) expressed in HEK293 cells assessed as suppression of NF-kB activation after 24 hrs by luciferase rep...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair