BDBM50273344 CHEMBL4128888

SMILES: Nc1cccnc1N1CCC(CC1)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1

InChI Key: InChIKey=XRLOYXFJBUUMBI-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50273344   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273344 (CHEMBL4128888) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C18H19ClN8O/c19-14-10-13(11-22-16(14)27-23-6-7-24-27)25-18(28)12-3-8-26(9-4-12)17-15(20)2-1-5-21-17/h1-2,5-7,10-12H,3-4,8-9,20H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	560	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISA				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273344 (CHEMBL4128888) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C18H19ClN8O/c19-14-10-13(11-22-16(14)27-23-6-7-24-27)25-18(28)12-3-8-26(9-4-12)17-15(20)2-1-5-21-17/h1-2,5-7,10-12H,3-4,8-9,20H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273344 (CHEMBL4128888) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C18H19ClN8O/c19-14-10-13(11-22-16(14)27-23-6-7-24-27)25-18(28)12-3-8-26(9-4-12)17-15(20)2-1-5-21-17/h1-2,5-7,10-12H,3-4,8-9,20H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of cIAP2 fused MALT1 (unknown origin) expressed in HEK293 cells assessed as suppression of NF-kB activation after 24 hrs by luciferase rep...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM50273344 (CHEMBL4128888) Show SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C18H19ClN8O/c19-14-10-13(11-22-16(14)27-23-6-7-24-27)25-18(28)12-3-8-26(9-4-12)17-15(20)2-1-5-21-17/h1-2,5-7,10-12H,3-4,8-9,20H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...				Bioorg Med Chem Lett 28: 2153-2158 (2018) Article DOI: 10.1016/j.bmcl.2018.05.017 BindingDB Entry DOI: 10.7270/Q2G73H89
					More data for this Ligand-Target Pair