BDBM50286492 2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one::CHEMBL132098
SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c3nn([C@@H]4CC[C@H](N)CC4)c(=O)c3cn(C3CC3)c2c1F
InChI Key: InChIKey=DSDIBKDSIAQRAN-MAEOIBBWSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase II (Homo sapiens (Human)) | BDBM50286492 (2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method | Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase II (Homo sapiens (Human)) | BDBM50286492 (2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation. | Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7 | |||||||||||
More data for this Ligand-Target Pair |