BDBM50297132 CHEMBL550527::endo-N-(3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,2-diphenylpropyl)methanesulfonamide

SMILES: CN1[C@@H]2CC[C@@H]1CC(CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2

InChI Key: InChIKey=NDHVOPDKZALZCQ-DHIUTWEWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297132   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50297132 (CHEMBL550527 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.28.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C24H32N2O2S/c1-26-22-13-14-23(26)16-19(15-22)17-24(18-25-29(2,27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,19,22-23,25H,13-18H2,1-2H3/t22-,23-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50297132 (CHEMBL550527 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.28.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C24H32N2O2S/c1-26-22-13-14-23(26)16-19(15-22)17-24(18-25-29(2,27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,19,22-23,25H,13-18H2,1-2H3/t22-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR				J Med Chem 52: 5241-52 (2010) Article DOI: 10.1021/jm900736e BindingDB Entry DOI: 10.7270/Q2PK0H54
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50297132 (CHEMBL550527 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.28.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C24H32N2O2S/c1-26-22-13-14-23(26)16-19(15-22)17-24(18-25-29(2,27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,19,22-23,25H,13-18H2,1-2H3/t22-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50297132 (CHEMBL550527 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.28.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C24H32N2O2S/c1-26-22-13-14-23(26)16-19(15-22)17-24(18-25-29(2,27)28,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,19,22-23,25H,13-18H2,1-2H3/t22-,23-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair