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BDBM50297472 5-chloro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL560344

SMILES: Fc1cc(CN2C(=O)C(N=O)c3cc(Cl)ccc23)c2OCOCc2c1

InChI Key: InChIKey=ZCLHYILVMNBSNR-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50297472   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50297472
PNG
(5-chloro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)...)
Show SMILES Fc1cc(CN2C(=O)C(N=O)c3cc(Cl)ccc23)c2OCOCc2c1
Show InChI InChI=1S/C17H12ClFN2O4/c18-11-1-2-14-13(5-11)15(20-23)17(22)21(14)6-9-3-12(19)4-10-7-24-8-25-16(9)10/h1-5,15H,6-8H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC cid
PC sid
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Patents

Article
PubMed
740n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by spectrophotometric coupled enzyme assay


Bioorg Med Chem Lett 19: 2891-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.043
More data for this
Ligand-Target Pair