BDBM50299249 1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde::CHEMBL583972::US8481586, 3

SMILES: O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21

InChI Key: InChIKey=VWNCOFUKBTYAON-UHFFFAOYSA-N

Data: 12 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50299249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique; Universite Blaise Pascal-Clermont-Ferrand II US Patent					Assay Description Inhibition assay using PIM-1, PIM-2 and PIM-3.				US Patent US8481586 (2013) BindingDB Entry DOI: 10.7270/Q2ZC81GT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique; Universite Blaise Pascal-Clermont-Ferrand II US Patent					Assay Description Inhibition assay using PIM-1, PIM-2 and PIM-3.				US Patent US8481586 (2013) BindingDB Entry DOI: 10.7270/Q2ZC81GT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique; Universite Blaise Pascal-Clermont-Ferrand II US Patent					Assay Description Inhibition assay using PIM-1, PIM-2 and PIM-3.				US Patent US8481586 (2013) BindingDB Entry DOI: 10.7270/Q2ZC81GT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of Pim-3				J Med Chem 52: 6369-81 (2009) Article DOI: 10.1021/jm901018f BindingDB Entry DOI: 10.7270/Q23F4PPS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of Pim-2				J Med Chem 52: 6369-81 (2009) Article DOI: 10.1021/jm901018f BindingDB Entry DOI: 10.7270/Q23F4PPS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Pim1 using RSRHSSYPAGT as substrate				Eur J Med Chem 56: 225-236 (2012) Article DOI: 10.1016/j.ejmech.2012.08.029 BindingDB Entry DOI: 10.7270/Q2XK8GTF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Université Curated by ChEMBL					Assay Description Inhibition of human GST fused Pim2 expressed in Escherichia coli after 30 mins				Bioorg Med Chem 18: 6865-73 (2010) Article DOI: 10.1016/j.bmc.2010.07.036 BindingDB Entry DOI: 10.7270/Q2PK0GBZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Université Curated by ChEMBL					Assay Description Inhibition of human GST fused Pim1 expressed in Escherichia coli after 30 mins				Bioorg Med Chem 18: 6865-73 (2010) Article DOI: 10.1016/j.bmc.2010.07.036 BindingDB Entry DOI: 10.7270/Q2PK0GBZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Université Curated by ChEMBL					Assay Description Inhibition of human GST fused Pim3 expressed in Escherichia coli after 30 mins				Bioorg Med Chem 18: 6865-73 (2010) Article DOI: 10.1016/j.bmc.2010.07.036 BindingDB Entry DOI: 10.7270/Q2PK0GBZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Pim2 using RSRHSSYPAGT as substrate				Eur J Med Chem 56: 225-236 (2012) Article DOI: 10.1016/j.ejmech.2012.08.029 BindingDB Entry DOI: 10.7270/Q2XK8GTF
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Pim3 using RSRHSSYPAGT as substrate				Eur J Med Chem 56: 225-236 (2012) Article DOI: 10.1016/j.ejmech.2012.08.029 BindingDB Entry DOI: 10.7270/Q2XK8GTF
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50299249 (1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde...) Show SMILES O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21 Show InChI InChI=1S/C15H10N2O/c18-8-9-7-16-14-10(9)5-6-12-11-3-1-2-4-13(11)17-15(12)14/h1-8,16-17H	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of Pim-1				J Med Chem 52: 6369-81 (2009) Article DOI: 10.1021/jm901018f BindingDB Entry DOI: 10.7270/Q23F4PPS
					More data for this Ligand-Target Pair				3D Structure (crystal)