BindingDB PrimarySearch

BDBM50303801 CHEMBL571546::N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide

SMILES: O=C(Cc1ccc(cn1)-c1ccc(OCCN2CCOCC2)cc1)NCc1ccccc1

InChI Key: InChIKey=HUNGUWOZPQBXGX-UHFFFAOYSA-N

Data: 8 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50303801
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of src kinase				J Med Chem 53: 1238-49 (2010) Article DOI: 10.1021/jm901525b BindingDB Entry DOI: 10.7270/Q2QJ7J72
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of c-SRC				Bioorg Med Chem 19: 2517-28 (2011) Article DOI: 10.1016/j.bmc.2011.03.021 BindingDB Entry DOI: 10.7270/Q2DN45CD
Institut de Recherches Servier Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of src kinase				J Med Chem 53: 1238-49 (2010) Article DOI: 10.1021/jm901525b BindingDB Entry DOI: 10.7270/Q2QJ7J72
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Bcr-Abl (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Inhibition of BCR/ABL (unknown origin)				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164
Athenex Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 1.5% FCS by BrdU incorporation assay				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164
Athenex Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 0.5% FCS				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164
Athenex Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Inhibition of LYN (unknown origin)				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164
Athenex Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Calmodulin/Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50303801 (CHEMBL571546 \| N-benzyl-2-(5-(4-(2-morpholinoethox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	6.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Inhibition of Src (unknown origin)				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164
Athenex Inc. Curated by ChEMBL					More data for this Ligand-Target Pair