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BDBM50306412 4-Benzyl-piperidine-1-carboxylic acid adamantan-2-ylamide::CHEMBL603885

SMILES: O=C(NC1C2CC3CC(C2)CC1C3)N1CCC(Cc2ccccc2)CC1

InChI Key: InChIKey=HIEVWEATEKEGPH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50306412   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50306412
PNG
(4-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)
Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)N1CCC(Cc2ccccc2)CC1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12,(-3.99,-11.29,;-3.95,-9.75,;-5.26,-8.94,;-6.61,-9.68,;-6.62,-11.2,;-8.02,-11.55,;-9.34,-11.06,;-10.54,-12.34,;-9.04,-11.92,;-7.64,-12.48,;-9.05,-10.32,;-8.01,-9.1,;-9.36,-9.57,;-2.59,-9.01,;-1.29,-9.82,;.06,-9.1,;.11,-7.56,;1.47,-6.83,;2.78,-7.64,;2.72,-9.17,;4.03,-9.98,;5.39,-9.25,;5.43,-7.71,;4.12,-6.9,;-1.2,-6.75,;-2.56,-7.48,)|
Show InChI InChI=1S/C23H32N2O/c26-23(24-22-20-12-18-11-19(14-20)15-21(22)13-18)25-8-6-17(7-9-25)10-16-4-2-1-3-5-16/h1-5,17-22H,6-15H2,(H,24,26)
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Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Vitae Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPA

Bioorg Med Chem Lett 20: 881-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.082
BindingDB Entry DOI: 10.7270/Q2KK9BWZ
More data for this
Ligand-Target Pair