BindingDB PrimarySearch

BDBM50306684 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide::CHEMBL602472

SMILES: C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl

InChI Key: InChIKey=QACCVOJRKKIYFM-SFNBMPIDSA-N

Data: 21 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50306684
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant PKCalpha by IMAP assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant c-Met by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant RON by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant CDK2 by IMAP assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant CDK1 by IMAP assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant AKT1 by IMAP assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Aurora A by IMAP assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Abl by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BRK (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant BRK by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant YES by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant EGFR by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Kit by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant LCK by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant IGF1R by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Fyn by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant Flt3 by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR2 by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte tyrosine kinase receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant LTK by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant EphA2 by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant AXL by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50306684 (2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant InsR by TR-FRET assay				Bioorg Med Chem Lett 20: 1405-9 (2010) Article DOI: 10.1016/j.bmcl.2009.12.109 BindingDB Entry DOI: 10.7270/Q2HQ401G
Chugai Pharmaceutical Co, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair