BindingDB PrimarySearch

BDBM50307878 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-oxo-2,3-dihydro-1Himidazo[4,5-b]pyridin-7-yloxy)phenyl)urea::CHEMBL597592

SMILES: CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cccc4[nH]c(=O)[nH]c34)c2)n(n1)-c1ccccc1

InChI Key: InChIKey=YLQMVIRZBOJBCV-UHFFFAOYSA-N

Data: 14 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50307878
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of FGFR1				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of FLT1				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of KDR				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of KIT				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	584	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of LCK				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of COT				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of wild type BRAF				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of p38alpha MAPK				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of MET				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of cRAF				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	698	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of RET				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM50307878 (1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of p38gamma MAPK				J Med Chem 53: 1964-78 (2010) Article DOI: 10.1021/jm901509a BindingDB Entry DOI: 10.7270/Q2R211HN
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair