BDBM50309549 3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione::CHEMBL606168::US9364459, O
SMILES: COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccc(F)cc12
InChI Key: InChIKey=HRUYZDJOLIPWLW-UHFFFAOYSA-N
Data: 11 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-Universität Mainz; Universitätsmedizin der Johannes Gutenberg-Universität Mainz US Patent | Assay Description The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con... | US Patent US9364459 (2016) BindingDB Entry DOI: 10.7270/Q2ZK5FK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of VEGFR3 after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of VEGFR2 after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of TIE2 after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of IGF1R after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of PDGFRalpha after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of KIT after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of ERBB2 after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of EGFR after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50309549 (3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of PDGFRbeta after 80 mins by radiometric protein kinase assay | Bioorg Med Chem 18: 612-20 (2010) Article DOI: 10.1016/j.bmc.2009.12.004 BindingDB Entry DOI: 10.7270/Q2DB820N | |||||||||||
More data for this Ligand-Target Pair |