BDBM50311646 (+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl)-7H-purin-8(9H)-one::CHEMBL1079525

SMILES: O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12

InChI Key: InChIKey=IYQNSOWQLSAIBF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50311646   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50311646 ((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...) Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12 Show InChI InChI=1S/C21H16N6O2/c28-21-24-15-11-22-20(26-12-23-14-6-2-3-7-17(14)26)25-19(15)27(21)16-9-10-29-18-8-4-1-5-13(16)18/h1-8,11-12,16H,9-10H2,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay				Bioorg Med Chem Lett 19: 6788-92 (2009) Article DOI: 10.1016/j.bmcl.2009.09.080 BindingDB Entry DOI: 10.7270/Q24B31G4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50311646 ((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...) Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12 Show InChI InChI=1S/C21H16N6O2/c28-21-24-15-11-22-20(26-12-23-14-6-2-3-7-17(14)26)25-19(15)27(21)16-9-10-29-18-8-4-1-5-13(16)18/h1-8,11-12,16H,9-10H2,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay				Bioorg Med Chem Lett 19: 6788-92 (2009) Article DOI: 10.1016/j.bmcl.2009.09.080 BindingDB Entry DOI: 10.7270/Q24B31G4
					More data for this Ligand-Target Pair