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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50311646'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50311646
PNG
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...)
Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12
Show InChI InChI=1S/C21H16N6O2/c28-21-24-15-11-22-20(26-12-23-14-6-2-3-7-17(14)26)25-19(15)27(21)16-9-10-29-18-8-4-1-5-13(16)18/h1-8,11-12,16H,9-10H2,(H,24,28)
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Ligand Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay

Bioorg Med Chem Lett 19: 6788-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4
More data for this
Ligand-Target Pair