BDBM50314790 CHEMBL1092013::N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide

SMILES: Cc1ccc(cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O)C(=O)NC1CC1

InChI Key: InChIKey=GYWNOAVEKDTRBQ-UHFFFAOYSA-N

Data: 4 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314790   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314790 (CHEMBL1092013 | N-Cyclopropyl-3-(1-(2-fluorophenyl...) Show SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O)C(=O)NC1CC1 Show InChI InChI=1S/C24H21FN4O2/c1-14-7-8-15(22(30)27-17-9-10-17)11-18(14)19-12-16-13-26-29(23(16)28(2)24(19)31)21-6-4-3-5-20(21)25/h3-8,11-13,17H,9-10H2,1-2H3,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to p38alpha by scintillation proximity assay				J Med Chem 53: 2973-85 (2010) Article DOI: 10.1021/jm100095x BindingDB Entry DOI: 10.7270/Q2FX79MD
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50314790 (CHEMBL1092013 | N-Cyclopropyl-3-(1-(2-fluorophenyl...) Show SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O)C(=O)NC1CC1 Show InChI InChI=1S/C24H21FN4O2/c1-14-7-8-15(22(30)27-17-9-10-17)11-18(14)19-12-16-13-26-29(23(16)28(2)24(19)31)21-6-4-3-5-20(21)25/h3-8,11-13,17H,9-10H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to c-Kit by scintillation proximity assay				J Med Chem 53: 2973-85 (2010) Article DOI: 10.1021/jm100095x BindingDB Entry DOI: 10.7270/Q2FX79MD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50314790 (CHEMBL1092013 | N-Cyclopropyl-3-(1-(2-fluorophenyl...) Show SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O)C(=O)NC1CC1 Show InChI InChI=1S/C24H21FN4O2/c1-14-7-8-15(22(30)27-17-9-10-17)11-18(14)19-12-16-13-26-29(23(16)28(2)24(19)31)21-6-4-3-5-20(21)25/h3-8,11-13,17H,9-10H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to Lck by scintillation proximity assay				J Med Chem 53: 2973-85 (2010) Article DOI: 10.1021/jm100095x BindingDB Entry DOI: 10.7270/Q2FX79MD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50314790 (CHEMBL1092013 | N-Cyclopropyl-3-(1-(2-fluorophenyl...) Show SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccccc3F)c2n(C)c1=O)C(=O)NC1CC1 Show InChI InChI=1S/C24H21FN4O2/c1-14-7-8-15(22(30)27-17-9-10-17)11-18(14)19-12-16-13-26-29(23(16)28(2)24(19)31)21-6-4-3-5-20(21)25/h3-8,11-13,17H,9-10H2,1-2H3,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to Kdr by scintillation proximity assay				J Med Chem 53: 2973-85 (2010) Article DOI: 10.1021/jm100095x BindingDB Entry DOI: 10.7270/Q2FX79MD
					More data for this Ligand-Target Pair