BindingDB PrimarySearch

BDBM50317323 CHEMBL1094718::N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

SMILES: Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1

InChI Key: InChIKey=DVRMYRDLCLUXQP-UHFFFAOYSA-N

Data: 14 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50317323
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met-mediated cell migration of human A549 cells by would healing				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
ChemRF Laboratories Curated by ChEMBL					Assay Description Inhibition of phosphorylation of c-Met in human MKN45 cells				Bioorg Med Chem Lett 25: 2527-31 (2015) Article DOI: 10.1016/j.bmcl.2015.04.056 BindingDB Entry DOI: 10.7270/Q21C1ZMR
ChemRF Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
ChemRF Laboratories Curated by ChEMBL					Assay Description Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA				Bioorg Med Chem Lett 25: 2527-31 (2015) Article DOI: 10.1016/j.bmcl.2015.04.056 BindingDB Entry DOI: 10.7270/Q21C1ZMR
ChemRF Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of VEGFR2				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
ChemRF Laboratories Curated by ChEMBL					Assay Description Inhibition of RON phosphorylation in human HT29 cells				Bioorg Med Chem Lett 25: 2527-31 (2015) Article DOI: 10.1016/j.bmcl.2015.04.056 BindingDB Entry DOI: 10.7270/Q21C1ZMR
ChemRF Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc. Curated by ChEMBL					Assay Description Inhibition of human RON				Bioorg Med Chem Lett 25: 3706-10 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1NDW
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc. Curated by ChEMBL					Assay Description Inhibition of human c-Met				Bioorg Med Chem Lett 25: 3706-10 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1NDW
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires ChemRF Inc./ChemRF Laboratories Inc. Curated by ChEMBL					Assay Description Inhibition of human RON				Bioorg Med Chem Lett 25: 3810-5 (2015) BindingDB Entry DOI: 10.7270/Q2028T99
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoires ChemRF Inc./ChemRF Laboratories Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human MKN45 cells				Bioorg Med Chem Lett 25: 3810-5 (2015) BindingDB Entry DOI: 10.7270/Q2028T99
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human MKN45 cells				Bioorg Med Chem Lett 20: 2745-9 (2010) Article DOI: 10.1016/j.bmcl.2010.03.073 BindingDB Entry DOI: 10.7270/Q24T6JJ6
MethylGene Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50317323 (CHEMBL1094718 \| N-(3-fluoro-4-(2-(1-methyl-1H-imid...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
ChemRF Laboratories Curated by ChEMBL					Assay Description Inhibition of RON phosphorylation in human PC3 cells				Bioorg Med Chem Lett 25: 2527-31 (2015) Article DOI: 10.1016/j.bmcl.2015.04.056 BindingDB Entry DOI: 10.7270/Q21C1ZMR
ChemRF Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair