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BDBM50320100 1-(2-((7-fluoro-5-methoxy-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indol-3-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-5-yl)-3-(4-(morpholine-4-carbonyl)phenyl)urea::CHEMBL1082620

SMILES: COc1cc(F)c2[nH]c(c(\C=C3\Oc4ccc(NC(=O)Nc5ccc(cc5)C(=O)N5CCOCC5)cc4C3=O)c2c1)-c1c(C)nn(C)c1C

InChI Key: InChIKey=NPQPJCWZDJSQHJ-UXHLAJHPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50320100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50320100
PNG
(1-(2-((7-fluoro-5-methoxy-2-(1,3,5-trimethyl-1H-py...)
Show SMILES COc1cc(F)c2[nH]c(c(\C=C3\Oc4ccc(NC(=O)Nc5ccc(cc5)C(=O)N5CCOCC5)cc4C3=O)c2c1)-c1c(C)nn(C)c1C |(-4.1,-10.42,;-4.1,-11.96,;-2.77,-12.73,;-2.77,-14.28,;-1.43,-15.05,;-1.43,-16.58,;-.1,-14.27,;1.37,-14.74,;2.27,-13.49,;1.37,-12.24,;1.96,-10.82,;1.2,-9.49,;1.82,-8.08,;.67,-7.06,;.67,-5.53,;-.65,-4.75,;-1.98,-5.53,;-3.32,-4.77,;-3.33,-3.22,;-2,-2.45,;-4.67,-2.46,;-4.68,-.93,;-3.35,-.16,;-3.36,1.37,;-4.7,2.13,;-6.02,1.35,;-6.01,-.18,;-4.71,3.67,;-3.39,4.45,;-6.04,4.42,;-6.05,5.96,;-7.38,6.72,;-8.71,5.95,;-8.7,4.41,;-7.36,3.65,;-1.98,-7.07,;-.65,-7.82,;-.33,-9.33,;-1.36,-10.48,;-.1,-12.73,;-1.44,-11.96,;3.81,-13.49,;4.72,-14.74,;4.24,-16.21,;6.18,-14.27,;6.18,-12.73,;7.43,-11.82,;4.71,-12.24,;4.24,-10.78,)|
Show InChI InChI=1S/C36H33FN6O6/c1-19-31(20(2)42(3)41-19)33-26(25-16-24(47-4)17-28(37)32(25)40-33)18-30-34(44)27-15-23(9-10-29(27)49-30)39-36(46)38-22-7-5-21(6-8-22)35(45)43-11-13-48-14-12-43/h5-10,15-18,40H,11-14H2,1-4H3,(H2,38,39,46)/b30-18+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 20: 3526-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.139
BindingDB Entry DOI: 10.7270/Q2FQ9WSC
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50320100
PNG
(1-(2-((7-fluoro-5-methoxy-2-(1,3,5-trimethyl-1H-py...)
Show SMILES COc1cc(F)c2[nH]c(c(\C=C3\Oc4ccc(NC(=O)Nc5ccc(cc5)C(=O)N5CCOCC5)cc4C3=O)c2c1)-c1c(C)nn(C)c1C |(-4.1,-10.42,;-4.1,-11.96,;-2.77,-12.73,;-2.77,-14.28,;-1.43,-15.05,;-1.43,-16.58,;-.1,-14.27,;1.37,-14.74,;2.27,-13.49,;1.37,-12.24,;1.96,-10.82,;1.2,-9.49,;1.82,-8.08,;.67,-7.06,;.67,-5.53,;-.65,-4.75,;-1.98,-5.53,;-3.32,-4.77,;-3.33,-3.22,;-2,-2.45,;-4.67,-2.46,;-4.68,-.93,;-3.35,-.16,;-3.36,1.37,;-4.7,2.13,;-6.02,1.35,;-6.01,-.18,;-4.71,3.67,;-3.39,4.45,;-6.04,4.42,;-6.05,5.96,;-7.38,6.72,;-8.71,5.95,;-8.7,4.41,;-7.36,3.65,;-1.98,-7.07,;-.65,-7.82,;-.33,-9.33,;-1.36,-10.48,;-.1,-12.73,;-1.44,-11.96,;3.81,-13.49,;4.72,-14.74,;4.24,-16.21,;6.18,-14.27,;6.18,-12.73,;7.43,-11.82,;4.71,-12.24,;4.24,-10.78,)|
Show InChI InChI=1S/C36H33FN6O6/c1-19-31(20(2)42(3)41-19)33-26(25-16-24(47-4)17-28(37)32(25)40-33)18-30-34(44)27-15-23(9-10-29(27)49-30)39-36(46)38-22-7-5-21(6-8-22)35(45)43-11-13-48-14-12-43/h5-10,15-18,40H,11-14H2,1-4H3,(H2,38,39,46)/b30-18+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha


Bioorg Med Chem Lett 20: 3526-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.139
BindingDB Entry DOI: 10.7270/Q2FQ9WSC
More data for this
Ligand-Target Pair