BDBM50321943 CHEMBL1172957::N-(4-Aminosulfonylphenyl)-2-morpholino-9H-purin-6-amine

SMILES: NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1

InChI Key: InChIKey=CMWKVPYIDPPPIC-UHFFFAOYSA-N

Data: 13 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50321943   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition cSRC				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition cMet				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition EphB2				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition EphA2				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition FGFR2				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition FGFR1				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition cABl				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition VEGFR1				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition KDR				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition ErbB2				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition EGFR				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition kit				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50321943 (CHEMBL1172957 | N-(4-Aminosulfonylphenyl)-2-morpho...) Show SMILES NS(=O)(=O)c1ccc(Nc2nc(nc3nc[nH]c23)N2CCOCC2)cc1 Show InChI InChI=1S/C15H17N7O3S/c16-26(23,24)11-3-1-10(2-4-11)19-14-12-13(18-9-17-12)20-15(21-14)22-5-7-25-8-6-22/h1-4,9H,5-8H2,(H2,16,23,24)(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition PDGFRbeta				Bioorg Med Chem 18: 4615-24 (2011) Article DOI: 10.1016/j.bmc.2010.05.032 BindingDB Entry DOI: 10.7270/Q26H4JCQ
					More data for this Ligand-Target Pair