BDBM50326208 4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine::CHEMBL1243326

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1

InChI Key: InChIKey=DZICJKNDYKNBTO-UHFFFAOYSA-N

Data: 16 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50326208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst staining				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK5 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of p70s6k by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PKBbeta by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha 5 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of MSK1 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of EGFR by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of EphB4 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of IGFR1 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Zap70 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Jak2 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Jak3 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of BTK by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of JNK2 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PLK1 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Erk1 by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PKBalpha by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50326208 (4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B by HTRF assay				J Med Chem 53: 6368-77 (2010) Article DOI: 10.1021/jm100394y BindingDB Entry DOI: 10.7270/Q2C829H0
					More data for this Ligand-Target Pair