BDBM50328347 CHEMBL1257800::diethyl 2-morpholino-4-phenyl-7-(3,3,3-trifluoropropyl)pyrrolo[1,2-b]pyridazine-5,6-dicarboxylate

SMILES: CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1

InChI Key: InChIKey=YQOCGVRFFGLKAK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328347   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50328347 (CHEMBL1257800 | diethyl 2-morpholino-4-phenyl-7-(3...) Show SMILES CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1 Show InChI InChI=1S/C26H28F3N3O5/c1-3-36-24(33)21-19(10-11-26(27,28)29)32-23(22(21)25(34)37-4-2)18(17-8-6-5-7-9-17)16-20(30-32)31-12-14-35-15-13-31/h5-9,16H,3-4,10-15H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50328347 (CHEMBL1257800 | diethyl 2-morpholino-4-phenyl-7-(3...) Show SMILES CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1 Show InChI InChI=1S/C26H28F3N3O5/c1-3-36-24(33)21-19(10-11-26(27,28)29)32-23(22(21)25(34)37-4-2)18(17-8-6-5-7-9-17)16-20(30-32)31-12-14-35-15-13-31/h5-9,16H,3-4,10-15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair