BDBM50328366 CHEMBL1257328::diethyl 4-phenyl-7-propyl-2-(pyrrolidin-1-yl)pyrrolo[1,2-b]pyridazine-5,6-dicarboxylate

SMILES: CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1

InChI Key: InChIKey=IETVRBGXAAGBAA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50328366 (CHEMBL1257328 | diethyl 4-phenyl-7-propyl-2-(pyrro...) Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1 Show InChI InChI=1S/C26H31N3O4/c1-4-12-20-22(25(30)32-5-2)23(26(31)33-6-3)24-19(18-13-8-7-9-14-18)17-21(27-29(20)24)28-15-10-11-16-28/h7-9,13-14,17H,4-6,10-12,15-16H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50328366 (CHEMBL1257328 | diethyl 4-phenyl-7-propyl-2-(pyrro...) Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1 Show InChI InChI=1S/C26H31N3O4/c1-4-12-20-22(25(30)32-5-2)23(26(31)33-6-3)24-19(18-13-8-7-9-14-18)17-21(27-29(20)24)28-15-10-11-16-28/h7-9,13-14,17H,4-6,10-12,15-16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs				Bioorg Med Chem Lett 20: 6030-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.066 BindingDB Entry DOI: 10.7270/Q2RV0NX1
					More data for this Ligand-Target Pair