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SMILES: Cc1n(CCc2c[nH]c3ccccc23)c(=O)cc2n(Cc3ccc(F)cc3)n(-c3ccccc3)c(=O)c12

InChI Key: InChIKey=GQGQOPNIMHBAOH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330699   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50330699
PNG
(5-(2-(1H-indol-3-yl)ethyl)-1-(4-fluorobenzyl)-4-me...)
Show SMILES Cc1n(CCc2c[nH]c3ccccc23)c(=O)cc2n(Cc3ccc(F)cc3)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C30H25FN4O2/c1-20-29-27(17-28(36)33(20)16-15-22-18-32-26-10-6-5-9-25(22)26)34(19-21-11-13-23(31)14-12-21)35(30(29)37)24-7-3-2-4-8-24/h2-14,17-18,32H,15-16,19H2,1H3
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PubMed
>3.00E+4n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH

J Med Chem 53: 7715-30 (2010)


Article DOI: 10.1021/jm100773e
BindingDB Entry DOI: 10.7270/Q2KH0NKJ
More data for this
Ligand-Target Pair