BDBM50331031 (Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-morpholin-4-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one::CHEMBL1277071

SMILES: Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(CCN3CCOCC3)C(=O)c12

InChI Key: InChIKey=GRDPLDYSIKQSRC-JXAWBTAJSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331031   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331031 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(CCN3CCOCC3)C(=O)c12 Show InChI InChI=1S/C24H27FN4O3/c1-15-21(14-18-17-13-16(25)4-5-19(17)27-23(18)30)26-20-3-2-6-29(24(31)22(15)20)8-7-28-9-11-32-12-10-28/h4-5,13-14,26H,2-3,6-12H2,1H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331031 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(CCN3CCOCC3)C(=O)c12 Show InChI InChI=1S/C24H27FN4O3/c1-15-21(14-18-17-13-16(25)4-5-19(17)27-23(18)30)26-20-3-2-6-29(24(31)22(15)20)8-7-28-9-11-32-12-10-28/h4-5,13-14,26H,2-3,6-12H2,1H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B method				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50331031 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(CCN3CCOCC3)C(=O)c12 Show InChI InChI=1S/C24H27FN4O3/c1-15-21(14-18-17-13-16(25)4-5-19(17)27-23(18)30)26-20-3-2-6-29(24(31)22(15)20)8-7-28-9-11-32-12-10-28/h4-5,13-14,26H,2-3,6-12H2,1H3,(H,27,30)/b18-14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Kit after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50331031 ((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...) Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCCN(CCN3CCOCC3)C(=O)c12 Show InChI InChI=1S/C24H27FN4O3/c1-15-21(14-18-17-13-16(25)4-5-19(17)27-23(18)30)26-20-3-2-6-29(24(31)22(15)20)8-7-28-9-11-32-12-10-28/h4-5,13-14,26H,2-3,6-12H2,1H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human PDGFRbeta after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair