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SMILES: Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(F)cc2F)[nH]n1

InChI Key: InChIKey=XHTUTACCUMHKNS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50337342   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50337342
PNG
(2-(2,6-difluorophenyl)-1-(4-(4-(5-methyl-1H-pyrazo...)
Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(F)cc2F)[nH]n1
Show InChI InChI=1S/C22H22F2N8O/c1-14-11-19(28-27-14)25-21-18-3-2-6-32(18)29-22(26-21)31-9-7-30(8-10-31)20(33)12-15-4-5-16(23)13-17(15)24/h2-6,11,13H,7-10,12H2,1H3,(H2,25,26,27,28,29)
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Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 after 60 mins

Bioorg Med Chem Lett 21: 1425-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.022
BindingDB Entry DOI: 10.7270/Q2MG7PRT
More data for this
Ligand-Target Pair