BDBM50337831 CHEMBL1683899::N,N-dimethyl-1-(1-(naphthalen-1-yl)cyclohexyl)methanamine::US10562878, Compound 53
SMILES: CN(C)CC1(CCCCC1)c1cccc2ccccc12
InChI Key: InChIKey=UTQLEVQLADDVHS-UHFFFAOYSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant dopamine transporter | Bioorg Med Chem Lett 21: 1438-41 (2011) Article DOI: 10.1016/j.bmcl.2011.01.016 BindingDB Entry DOI: 10.7270/Q2S46S72 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant Norepinephrine transporter | Bioorg Med Chem Lett 21: 1438-41 (2011) Article DOI: 10.1016/j.bmcl.2011.01.016 BindingDB Entry DOI: 10.7270/Q2S46S72 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus (rat)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepinephrine & serotonin (Rattus norvegicus (rat)) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming 1 (Rat) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337831 (CHEMBL1683899 | N,N-dimethyl-1-(1-(naphthalen-1-yl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair |