BDBM50337910 (+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine::1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine::CHEMBL1684045::CHEMBL1684057::US10562878, Compound 108
SMILES: CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=ZJNJPYFFMXVAGY-UHFFFAOYSA-N
Data: 42 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C19 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of CYP2C19 | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of CYP2C9 | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of CYP3A4 | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of CYP2D6 | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepinephrine & serotonin (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming 1 (Rat) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepinephrine & serotonin (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming 1 (Rat) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 441 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 297 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepinephrine & serotonin (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming 1 (Rat) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepinephrine & serotonin (Rattus norvegicus (rat)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming 1 (Rat) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337910 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair |