BDBM50340134 CHEMBL1760047::N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES: COc1cc(Nc2nccc(Nc3ccccn3)n2)cc(OC)c1OC

InChI Key: InChIKey=VBXMNDHXPKBZOQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340134   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340134 (CHEMBL1760047 | N4-(pyridin-2-yl)-N2-(3,4,5-trimet...) Show SMILES COc1cc(Nc2nccc(Nc3ccccn3)n2)cc(OC)c1OC Show InChI InChI=1S/C18H19N5O3/c1-24-13-10-12(11-14(25-2)17(13)26-3)21-18-20-9-7-16(23-18)22-15-6-4-5-8-19-15/h4-11H,1-3H3,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human IGF1R				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair