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BDBM50341784 CHEMBL1766894::N-(2-(2-phenyl-5-(trifluoromethyl)-1H-imidazole-4-carboxamido)ethyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

SMILES: FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1[nH]c(nc1C(F)(F)F)-c1ccccc1

InChI Key: InChIKey=ISJOQUCYPIZCNB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50341784   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))		BDBM50341784
PNG
(CHEMBL1766894 | N-(2-(2-phenyl-5-(trifluoromethyl)...)
Show SMILES FC(F)(F)COc1ccc(cn1)C(=O)NCCNC(=O)c1[nH]c(nc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C21H17F6N5O3/c22-20(23,24)11-35-14-7-6-13(10-30-14)18(33)28-8-9-29-19(34)15-16(21(25,26)27)32-17(31-15)12-4-2-1-3-5-12/h1-7,10H,8-9,11H2,(H,28,33)(H,29,34)(H,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysis

J Med Chem 54: 2433-46 (2011)


Article DOI: 10.1021/jm101580m
BindingDB Entry DOI: 10.7270/Q2S182TQ
More data for this
Ligand-Target Pair