BDBM50343216 CHEMBL1773583::N-(6-(2-(Phenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(Sc2ccccc2)n1

InChI Key: InChIKey=HGJJNVJRVBALPQ-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50343216 (CHEMBL1773583 | N-(6-(2-(Phenylthio)pyrimidin-4-yl...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(Sc2ccccc2)n1 Show InChI InChI=1S/C19H14N4OS2/c1-12(24)21-19-23-16-8-7-13(11-17(16)26-19)15-9-10-20-18(22-15)25-14-5-3-2-4-6-14/h2-11H,1H3,(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50343216 (CHEMBL1773583 | N-(6-(2-(Phenylthio)pyrimidin-4-yl...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(Sc2ccccc2)n1 Show InChI InChI=1S/C19H14N4OS2/c1-12(24)21-19-23-16-8-7-13(11-17(16)26-19)15-9-10-20-18(22-15)25-14-5-3-2-4-6-14/h2-11H,1H3,(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair