Found 5 hits for monomerid = 50360683 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM50360683
(CHEMBL1934130)Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HE... |
Bioorg Med Chem Lett 22: 363-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.125 BindingDB Entry DOI: 10.7270/Q2VD6ZW1 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50360683
(CHEMBL1934130)Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of dopamine D2 receptor |
Bioorg Med Chem Lett 22: 363-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.125 BindingDB Entry DOI: 10.7270/Q2VD6ZW1 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50360683
(CHEMBL1934130)Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of serotonin transporter |
Bioorg Med Chem Lett 22: 363-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.125 BindingDB Entry DOI: 10.7270/Q2VD6ZW1 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50360683
(CHEMBL1934130)Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human ERG by rubidium [86Rb] efflux assay |
Bioorg Med Chem Lett 22: 363-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.125 BindingDB Entry DOI: 10.7270/Q2VD6ZW1 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM50360683
(CHEMBL1934130)Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12 |r| Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ... |
Bioorg Med Chem Lett 22: 363-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.125 BindingDB Entry DOI: 10.7270/Q2VD6ZW1 |
More data for this Ligand-Target Pair | |