BDBM50367222 CHEMBL4162778
SMILES: [Na;v0+].[#6]-[#8]-c1ccc(F)c(c1)-c1ccc(nc1)-[#6]-1-[#6]-[#6]-c2ccc(cc2-[#8]-1)-[#6@@H](-[#6@H](-[#6])-[#6](-[#8-])=O)-[#6]-1-[#6]-[#6]-1
InChI Key: InChIKey=URVJPHDSDQPGJZ-UCXMRBTASA-M
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ... | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 120 (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | Reactome pathway KEGG GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at GPR120 (unknown origin) | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 247 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of ... | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins in presence of ... | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Rattus norvegicus) | BDBM50367222 (CHEMBL4162778) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM50367222 (CHEMBL4162778) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assay | ACS Med Chem Lett 9: 685-690 (2018) Article DOI: 10.1021/acsmedchemlett.8b00149 BindingDB Entry DOI: 10.7270/Q29C70ZD | |||||||||||
More data for this Ligand-Target Pair |