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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bile salt export pump' and Ligand = 'BDBM50367222'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bile salt export pump


(Homo sapiens (Human))		BDBM50367222
PNG
(CHEMBL4162778)
Show SMILES [Na;v0+].[#6]-[#8]-c1ccc(F)c(c1)-c1ccc(nc1)-[#6]-1-[#6]-[#6]-c2ccc(cc2-[#8]-1)-[#6@@H](-[#6@H](-[#6])-[#6](-[#8-])=O)-[#6]-1-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C28H28FNO4.Na/c1-16(28(31)32)27(18-4-5-18)19-6-3-17-8-12-25(34-26(17)13-19)24-11-7-20(15-30-24)22-14-21(33-2)9-10-23(22)29;/h3,6-7,9-11,13-16,18,25,27H,4-5,8,12H2,1-2H3,(H,31,32);/q;+1/p-1/t16-,25?,27-;/m0./s1
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Similars
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Merck & Co.

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus infected Sf9 insect cell membrane vesicles assessed as reduction in ATP-dependent [3H]-taurocholic ...

ACS Med Chem Lett 9: 685-690 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00149
BindingDB Entry DOI: 10.7270/Q29C70ZD
More data for this
Ligand-Target Pair