BDBM50380626 CHEMBL2016874
SMILES: NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)n4)nn3)cc1
InChI Key: InChIKey=PODBMIDYMFKRKE-URLMMPGGSA-N
Data: 9 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of plasmin by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of plasma kallikrein by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasma kallikrein (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of factor 10a by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Medicines Company (Leipzig) GmbH US Patent | Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo... | US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of thrombin by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K-dependent protein C (Homo sapiens (Human)) | BDBM50380626 (CHEMBL2016874) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg Curated by ChEMBL | Assay Description Inhibition of activated protein C by dixon plot method | J Med Chem 55: 1171-80 (2012) Article DOI: 10.1021/jm2011996 BindingDB Entry DOI: 10.7270/Q26T0NN4 | |||||||||||
More data for this Ligand-Target Pair |