Found 4 hits for monomerid = 50382822 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50382822
(CHEMBL2023587)Show SMILES CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 |TLB:1:2:4:8.6.7,THB:6:5:2:8.7.9,6:7:4.5.11:2,9:7:4:11.10.2,9:10:4:8.6.7,(27.44,-30.3,;27.44,-31.84,;28.77,-32.61,;28.78,-34.1,;27.59,-35.37,;29.08,-34.95,;30.49,-35.52,;31.5,-34.24,;30.1,-34.59,;31.52,-32.71,;30.11,-32.13,;29.07,-33.37,;26.11,-32.61,;26.1,-34.15,;24.77,-31.84,;23.44,-32.61,;22.1,-31.83,;22.11,-30.29,;20.78,-29.52,;19.44,-30.29,;19.44,-31.84,;20.77,-32.61,;18.1,-32.6,;16.77,-31.83,;15.44,-32.61,;14.1,-31.84,;14.1,-30.29,;12.77,-29.52,;15.43,-29.52,;16.77,-30.28,;18.1,-29.51,;17.32,-28.17,;18.86,-28.17,;23.44,-29.52,;24.77,-30.29,)| Show InChI InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA |
Bioorg Med Chem Lett 22: 2748-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.095
BindingDB Entry DOI: 10.7270/Q22F7PGX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50382822
(CHEMBL2023587)Show SMILES CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 |TLB:1:2:4:8.6.7,THB:6:5:2:8.7.9,6:7:4.5.11:2,9:7:4:11.10.2,9:10:4:8.6.7,(27.44,-30.3,;27.44,-31.84,;28.77,-32.61,;28.78,-34.1,;27.59,-35.37,;29.08,-34.95,;30.49,-35.52,;31.5,-34.24,;30.1,-34.59,;31.52,-32.71,;30.11,-32.13,;29.07,-33.37,;26.11,-32.61,;26.1,-34.15,;24.77,-31.84,;23.44,-32.61,;22.1,-31.83,;22.11,-30.29,;20.78,-29.52,;19.44,-30.29,;19.44,-31.84,;20.77,-32.61,;18.1,-32.6,;16.77,-31.83,;15.44,-32.61,;14.1,-31.84,;14.1,-30.29,;12.77,-29.52,;15.43,-29.52,;16.77,-30.28,;18.1,-29.51,;17.32,-28.17,;18.86,-28.17,;23.44,-29.52,;24.77,-30.29,)| Show InChI InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA |
Bioorg Med Chem Lett 22: 2748-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.095
BindingDB Entry DOI: 10.7270/Q22F7PGX |
More data for this
Ligand-Target Pair | |
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2)
(Mus musculus (mouse)) | BDBM50382822
(CHEMBL2023587)Show SMILES CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 |TLB:1:2:4:8.6.7,THB:6:5:2:8.7.9,6:7:4.5.11:2,9:7:4:11.10.2,9:10:4:8.6.7,(27.44,-30.3,;27.44,-31.84,;28.77,-32.61,;28.78,-34.1,;27.59,-35.37,;29.08,-34.95,;30.49,-35.52,;31.5,-34.24,;30.1,-34.59,;31.52,-32.71,;30.11,-32.13,;29.07,-33.37,;26.11,-32.61,;26.1,-34.15,;24.77,-31.84,;23.44,-32.61,;22.1,-31.83,;22.11,-30.29,;20.78,-29.52,;19.44,-30.29,;19.44,-31.84,;20.77,-32.61,;18.1,-32.6,;16.77,-31.83,;15.44,-32.61,;14.1,-31.84,;14.1,-30.29,;12.77,-29.52,;15.43,-29.52,;16.77,-30.28,;18.1,-29.51,;17.32,-28.17,;18.86,-28.17,;23.44,-29.52,;24.77,-30.29,)| Show InChI InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA |
Bioorg Med Chem Lett 22: 2748-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.095
BindingDB Entry DOI: 10.7270/Q22F7PGX |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 2
(Homo sapiens (Human)) | BDBM50382822
(CHEMBL2023587)Show SMILES CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 |TLB:1:2:4:8.6.7,THB:6:5:2:8.7.9,6:7:4.5.11:2,9:7:4:11.10.2,9:10:4:8.6.7,(27.44,-30.3,;27.44,-31.84,;28.77,-32.61,;28.78,-34.1,;27.59,-35.37,;29.08,-34.95,;30.49,-35.52,;31.5,-34.24,;30.1,-34.59,;31.52,-32.71,;30.11,-32.13,;29.07,-33.37,;26.11,-32.61,;26.1,-34.15,;24.77,-31.84,;23.44,-32.61,;22.1,-31.83,;22.11,-30.29,;20.78,-29.52,;19.44,-30.29,;19.44,-31.84,;20.77,-32.61,;18.1,-32.6,;16.77,-31.83,;15.44,-32.61,;14.1,-31.84,;14.1,-30.29,;12.77,-29.52,;15.43,-29.52,;16.77,-30.28,;18.1,-29.51,;17.32,-28.17,;18.86,-28.17,;23.44,-29.52,;24.77,-30.29,)| Show InChI InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA |
Bioorg Med Chem Lett 22: 2748-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.095
BindingDB Entry DOI: 10.7270/Q22F7PGX |
More data for this
Ligand-Target Pair | |
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