BDBM50394741 CHEMBL2165825

SMILES: CCNCCN1CCCc2cc(NC(=N)c3cccs3)ccc12

InChI Key: InChIKey=VBVXWUXOTZGHSU-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50394741   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50394741 (CHEMBL2165825) Show SMILES CCNCCN1CCCc2cc(NC(=N)c3cccs3)ccc12 Show InChI InChI=1S/C18H24N4S/c1-2-20-9-11-22-10-3-5-14-13-15(7-8-16(14)22)21-18(19)17-6-4-12-23-17/h4,6-8,12-13,20H,2-3,5,9-11H2,1H3,(H2,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential assessed as reduction in tail current amplitude by conventional patch c...				J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50394741 (CHEMBL2165825) Show SMILES CCNCCN1CCCc2cc(NC(=N)c3cccs3)ccc12 Show InChI InChI=1S/C18H24N4S/c1-2-20-9-11-22-10-3-5-14-13-15(7-8-16(14)22)21-18(19)17-6-4-12-23-17/h4,6-8,12-13,20H,2-3,5,9-11H2,1H3,(H2,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...				J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50394741 (CHEMBL2165825) Show SMILES CCNCCN1CCCc2cc(NC(=N)c3cccs3)ccc12 Show InChI InChI=1S/C18H24N4S/c1-2-20-9-11-22-10-3-5-14-13-15(7-8-16(14)22)21-18(19)17-6-4-12-23-17/h4,6-8,12-13,20H,2-3,5,9-11H2,1H3,(H2,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human eNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...				J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50394741 (CHEMBL2165825) Show SMILES CCNCCN1CCCc2cc(NC(=N)c3cccs3)ccc12 Show InChI InChI=1S/C18H24N4S/c1-2-20-9-11-22-10-3-5-14-13-15(7-8-16(14)22)21-18(19)17-6-4-12-23-17/h4,6-8,12-13,20H,2-3,5,9-11H2,1H3,(H2,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
NeurAxon Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated fo...				J Med Chem 55: 2882-93 (2012) Article DOI: 10.1021/jm3000449 BindingDB Entry DOI: 10.7270/Q24F1RV1
					More data for this Ligand-Target Pair