BDBM50398032 CHEMBL1603014
SMILES: CC(=O)c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)Cc2c1
InChI Key: InChIKey=IOWHNNUEAIMNRP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM50398032 (CHEMBL1603014) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences Curated by ChEMBL | Assay Description Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assay | J Med Chem 55: 7546-59 (2012) Article DOI: 10.1021/jm3005543 BindingDB Entry DOI: 10.7270/Q27945SS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM50398032 (CHEMBL1603014) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences Curated by ChEMBL | Assay Description Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assay | J Med Chem 55: 7546-59 (2012) Article DOI: 10.1021/jm3005543 BindingDB Entry DOI: 10.7270/Q27945SS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal alpha-glucosidase (Homo sapiens (Human)) | BDBM50398032 (CHEMBL1603014) | PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences Curated by ChEMBL | Assay Description Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assay | J Med Chem 55: 7546-59 (2012) Article DOI: 10.1021/jm3005543 BindingDB Entry DOI: 10.7270/Q27945SS | |||||||||||
More data for this Ligand-Target Pair |