Reaction Details |
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Target | Lysosomal alpha-glucosidase |
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Ligand | BDBM50398032 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_873176 (CHEMBL2183407) |
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IC50 | 940±n/a nM |
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Citation | Xiao, J; Westbroek, W; Motabar, O; Lea, WA; Hu, X; Velayati, A; Zheng, W; Southall, N; Gustafson, AM; Goldin, E; Sidransky, E; Liu, K; Simeonov, A; Tamargo, RJ; Ribes, A; Matalonga, L; Ferrer, M; Marugan, JJ Discovery of a novel noniminosugar acida glucosidase chaperone series. J Med Chem55:7546-59 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal alpha-glucosidase |
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Name: | Lysosomal alpha-glucosidase |
Synonyms: | 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 105312.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1506060 |
Residue: | 952 |
Sequence: | MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGA
SRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGA
QMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLH
FTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLF
FADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLA
LEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDG
FRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELEN
PPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISR
STFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVR
WTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAG
ETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPV
EALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQP
MALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQ
LQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
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BDBM50398032 |
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n/a |
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Name | BDBM50398032 |
Synonyms: | CHEMBL1603014 |
Type | Small organic molecule |
Emp. Form. | C20H21N3O4S |
Mol. Mass. | 399.463 |
SMILES | CC(=O)c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2NC(=O)Cc2c1 |
Structure |
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