BDBM50399680 CHEMBL2178948

SMILES: Cc1nc(C)c(nc1C(N)=O)-c1ccc2c(CC[C@]22CC[C@@H](CC2)C(O)=O)c1

InChI Key: InChIKey=QZOAOSNSNYIGEZ-XLOAEROZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50399680 (CHEMBL2178948) Show SMILES Cc1nc(C)c(nc1C(N)=O)-c1ccc2c(CC[C@]22CC[C@@H](CC2)C(O)=O)c1 |r,wU:21.26,wD:18.18,(32.89,-23.7,;34.23,-22.93,;35.57,-23.7,;36.9,-22.92,;38.23,-23.69,;36.9,-21.39,;35.56,-20.62,;34.23,-21.38,;32.9,-20.61,;31.56,-21.38,;32.9,-19.07,;38.23,-20.62,;38.23,-19.08,;39.56,-18.31,;40.89,-19.07,;40.9,-20.61,;42.37,-21.08,;43.27,-19.83,;42.35,-18.58,;43.84,-18.17,;44.23,-16.69,;43.14,-15.61,;41.65,-16.01,;41.26,-17.5,;43.53,-14.12,;45.02,-13.71,;42.44,-13.03,;39.56,-21.39,)| Show InChI InChI=1S/C22H25N3O3/c1-12-18(25-19(20(23)26)13(2)24-12)16-3-4-17-15(11-16)7-10-22(17)8-5-14(6-9-22)21(27)28/h3-4,11,14H,5-10H2,1-2H3,(H2,23,26)(H,27,28)/t14-,22+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography				J Med Chem 55: 10610-29 (2012) Article DOI: 10.1021/jm301296t BindingDB Entry DOI: 10.7270/Q2XD12T3
					More data for this Ligand-Target Pair