BDBM50402205 CHEMBL2203977

SMILES: NC(=O)c1cccc(Cn2ccc3cc(ccc23)-c2cc(cc(=O)n2O)-c2ccccc2)c1

InChI Key: InChIKey=ZTHCOUPARGEBHK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50402205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glyoxalase 1 (GLO1) (Homo sapiens (Human))	BDBM50402205 (CHEMBL2203977) Show SMILES NC(=O)c1cccc(Cn2ccc3cc(ccc23)-c2cc(cc(=O)n2O)-c2ccccc2)c1 Show InChI InChI=1S/C27H21N3O3/c28-27(32)22-8-4-5-18(13-22)17-29-12-11-21-14-20(9-10-24(21)29)25-15-23(16-26(31)30(25)33)19-6-2-1-3-7-19/h1-16,33H,17H2,(H2,28,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...				Bioorg Med Chem Lett 22: 7486-9 (2012) Article DOI: 10.1016/j.bmcl.2012.10.045 BindingDB Entry DOI: 10.7270/Q2RX9D8Q
					More data for this Ligand-Target Pair