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BDBM50413501 CHEMBL325327::SK&F-91486::SK-91486

SMILES: NC(N)=NCCCc1cnc[nH]1

InChI Key: InChIKey=VKPJPAPCRZIUMA-UHFFFAOYSA-N

Data: 3 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50413501   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/an/an/a 2.57E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.10n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair