BDBM50436989 CHEMBL2402904
SMILES: COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4nc([nH]c34)C(C)C)CC2)CC1
InChI Key: InChIKey=MZOITCJKGUIQEI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50436989 (CHEMBL2402904) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance, Inc. Curated by ChEMBL | Assay Description Binding affinity to human recombinant 5HT3 receptor | Bioorg Med Chem Lett 23: 4210-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.018 BindingDB Entry DOI: 10.7270/Q2F47QJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50436989 (CHEMBL2402904) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd. Curated by ChEMBL | Assay Description Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay | Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 4 (5-HT4) receptor (GUINEA PIG) | BDBM50436989 (CHEMBL2402904) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd. Curated by ChEMBL | Assay Description Agonist activity at 5-HT4 receptor in guinea pig colon | Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50436989 (CHEMBL2402904) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
Theravance, Inc. Curated by ChEMBL | Assay Description Induction of 5-HT4 receptor-mediated contraction in guinea pig longitudinal muscle myenteric plexus | Bioorg Med Chem Lett 23: 4210-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.018 BindingDB Entry DOI: 10.7270/Q2F47QJJ | |||||||||||
More data for this Ligand-Target Pair |